Psoriasis Research Summary

Chinese and Western medicine in China in 2001 combined meeting of Dermatovenereology, received from all parts of the country papers of the 185 psoriasis, categories, content-rich: A basic theory, experimental studies; dialectical type of Chinese medicine, Chinese medicine treatment mechanism; Chinese and Western medicines , internal external clinical experiences; new therapy, combination therapy for psoriasis and other advanced methods to explore the pathogenesis, reflecting the advanced nature of our academic standards, traditional Chinese and western medicine theory of the continuous deepening of traditional Chinese and western medicine on the treatment of psoriasis a new level.
Special lecture on the psoriasis and the relationship between cytokines. In psoriatic skin lesions: from interleukin-1α (IL1α) increased secretion; tumor necrosis factor-α (INF-α) have increased; IL2 increased; γ together dry Su-(IFN-γ) increased; IL12 increased expression; IL15 and IL15 binding activity were increased; IL10 and its receptor expression. In psoriatic lesions and increased serum IL6; psoriasis lesions鳞屑and suction blister fluid, the granulocyte-macrophage colony-stimulating factor (GM-CSF) increased; psoriatic skin lesions and by IL8 and IL8 body are increased, and does not increase serum IL8. Psoriatic lesions, the epidermal growth factor receptor (EGF) and its ligand TGF-α and increased expression of amphiregulin. Endothelin 1 (ET1) generally do not belong to the family of cytokines, but in structure and function can be considered as a cytokine, in serum and skin lesions of psoriasis in an increase in ET1. However, the incidence of psoriasis is not only concerned with individual cytokines, the role of the main network. Producing cells as a result of keratinocyte (KC) and skin-infiltrating T-cells can be seen as the protagonist of psoriasis, they produce a variety of cytokines will form a special network. In view of the above theory, treatment of psoriasis are: added Th2 or anti-inflammatory cytokines; inhibit or block the pro-inflammatory cytokines, cytokine gene therapy.
Experimental study of the many topics and related cytokines. Based on cytokine secretion patterns, CT4 cells into Th1 and Th2 subsets, Th1 secretion of IL2, INF-γ, etc., that is, Th1-type cytokines; Th2 major secreted IL4, IL6, IL10, etc., in order to TL2-type cytokines. The body to maintain normal Th1/Th2 balance in dynamic network. When the time Th1/Th2 imbalance, which is \ "Th1-Th2 \" drift. Experimental conclusion is that psoriasis is Th1-type response patterns may be the reasoning for the period, in peripheral blood levels of Th1-type cytokine-dominated; stable condition, Th1 cytokine levels, Th2-type cytokine levels. CTLA4Ig was constructed using gene recombination of a soluble chimeric protein, can be reduced Th1 type cytokines, increase of Th2 type cytokines, therefore, can be the treatment of psoriasis CTLA1Ig.
Lesions and peripheral blood in the transforming growth factor (CTGF-β) and receptor expression studies of TGF-β family's role in the pathogenesis, the results suggest that the skin lesions of psoriasis patients or peripheral blood, the existence of TGF-βm RNA expression, so that it can not effectively play the role of negative regulation, resulting in skin lesions or blood, cell proliferation in a transitional state, and dermal endothelial cells can not inhibit the inflammatory cells to the chemotactic effect, and psoriasis pathology change-related. Further on specific targets, such as an in-depth study, the treatment is expected to have a new breakthrough.
Skin lesions of patients with psoriasis vulgaris in keratinocyte growth factor (KGF) and nerve cell growth factor (NGF) in the epidermis of psoriatic keratinocyte proliferation, differentiation has a major role. KGF and its receptor (KGFR) and mainly expressed in basal cells in the grass-roots level; NGF and its receptor expression in the upper epidermis strong, there is weakening and the lower epidermis. Psoriasis patients with the expression of KGF and KGFR significantly increase; In addition, NGF into the outside in the remission period and the location of lesions on the expression of differentiated, suggesting that NGF could be used as an indicator of psoriasis patients.
IL8 and its receptor CXCR2 in psoriatic keratinocytes and the expression of the study results showed that: in patients with skin lesions of psoriasis keratinocytes secrete Department supernatant on neutrophil chemotactic capacity was stronger than the normal control group, the level of IL8 secretion was higher than normal, lesional keratinocytes Department of CXCR2 expression was significantly stronger than the normal control group. Show details www.npx100.com landing. From this description of local skin lesions of patients with psoriasis showed keratinocytes (KC) a high degree of keratinocyte proliferation and secretion of high, high expression of proliferation of the IL8 and its receptor CXCR2. Psoriasis vulgaris in angiogenesis-related factor, vascular endothelial growth factor (VEGF), monocyte chemotactic factor -1 (MCP-1) expression increased, both of which prompted the Senate in the pathogenesis of psoriasis.
Psoriasis calcitonin gene-related peptide secretion and research, results showed that peripheral sensory nerve endings from God peptide CGRP, through receptor-mediated effect on the Langerhans cells in skin lesions under certain conditions to increase its synthesis and secretion of chemokines to promote neutrophil angle in the epidermal layer of aggregation, as well as local inflammatory lymphocytes in the directional migration zone, in order to clarify the abnormal neuroimmunomodulation in the pathogenesis of psoriasis provide a basis. Nitric oxide can cause cultured keratinocytes CGMP increase, CGMP can be caused by increased keratinocyte proliferation; nitric oxide caused keratinocyte chemokine IL8 expression and the psoriatic lesions on the inflammatory cell infiltration. Nitric oxide-type enzyme in the founding of the abnormal expression of the psoriatic lesions, suggesting that nitric oxide and the pathogenesis of psoriasis clearance.
Psoriasis vulgaris in children in the tumor necrosis factor (INF) may be IL6, IL8 increased the main contributing factor, they may be induced or there is some kind of mutual synergies, the joint participation of the immune inflammatory psoriasis pathology process.
Psoriasis with streptococcal throat infection, and skin lesions in the author from the keratin 14 (K14) expression of and with the relationship between streptococcal M6 protein. Conclusions as follows: over-expression of psoriatic epidermal K14, pharyngeal infection with the Streptococcus M6 protein in patients with psoriasis than non-infected with Streptococcus M6 protein, a stronger expression of K14. Another study found that, M6 protein is not a specific area of hemolytic streptococcus pyogenes, if this protein is the trigger factor of psoriasis of the start-up, then with the Streptococcus M6 protein (suppurative streptococcus, Streptococcus agalactiae, it seems Streptococcus) and the incidence of guttate psoriasis have a significant correlation. In β-hemolytic streptococcus-induced model of the pathogenesis of psoriasis, the psoriasis patients to speculate the existence of β-hemolytic streptococcus (SP)-specific lymphocytes, SP as a super-antigen activation of these lymphocytes, after From the release of a large number of cytokines and synergy of these cells so that activation of keratinocyte proliferation, the expression of H-LA-DR, increase Fas antigen, activated T cells and FasL expression in keratinocytes of the Fas antigen-binding surface, induced keratinocyte apoptosis, that is, \ "activation-induced apoptosis in \", which constitutes a psoriasis clinical and pathological features.